Reactive species
Human,Mouse,Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of
human α-Synuclein
Dilution rate
WB 1:500-2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
PD1; NACP; PARK1; PARK4; α-Synuclein
Function
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gammasynuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein
inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and
membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of
Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of
patients with Alzheimer's disease. Alternatively spliced transcripts encoding different
isoforms have been identified for this gene
