Reactive species
Human,Mouse,Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 208-457 of
human NFS1 (NP_066923.3).
Dilution rate
WB 1:500-2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
IscS; NIFS; COXPD52; HUSSY-08; NFS1
Background
Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins
encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from
cysteine, creating alanine in the process. This gene uses alternate in-frame translation
initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of
the alternative initiation sites is determined by the cytosolic pH. The encoded proteins
belong to the class-V family of pyridoxal phosphate-dependent aminotransferases.
Alternatively spliced transcript variants have been described.
