Reactive species
Human,Mouse,Rat
Protein name
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Immunogen
AA range: 100-200
Specificity
This antibody detects endogenous levels of COX IV protein.
Constitute
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Dilution rate
WB 1:500-2000;
Purification process
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Stockpile
-15°C to -25°C/1 year(Do not lower than -25°C)
Other name
COX4I1 ;
COX4 ;
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial ;
Cytochrome c oxidase polypeptide IV ;
Cytochrome c oxidase subunit IV isoform 1 ;
COX IV-1
Background
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to this gene are located on chromosomes
Function
Function:This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.,similarity:Belongs to the cytochrome c oxidase IV family.,tissue specificity:Ubiquitous.,
