Reactive species
Human,Mouse,Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of
human MDC1 (NP_055456.2).
Dilution rate
WB 1:500-2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Function
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 Cterminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-
amino acid sequence. The encoded protein is required to activate the intra-S phase and
G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein
interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through
its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11
protein complex to DNA damage foci.
