Background
This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing
results in multiple transcript variants, at least one of which encodes a preproprotein that is
proteolytically processed to generate a regulatory propeptide and the mature enzyme. The
copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of
collagens and elastin, while the propeptide may play a role in tumor suppression. In addition,
defects in this gene have been linked with predisposition to thoracic aortic aneurysms and
dissections
