Reactive species
Human,Mouse,Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 216-485 of
human POLG2 (NP_009146.2).
Dilution rate
WB 1:500-2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
HP55; POLB; PEOA4; POLGB; MTPOLB; MTDPS16; MTDPS16A; MTDPS16B; POLG-BETA; POLG2
Background
This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma.
The encoded protein forms a heterotrimer containing one catalytic subunit and two
processivity subunits. This protein enhances DNA binding and promotes processive DNA
synthesis. Mutations in this gene result in autosomal dominant progressive external
ophthalmoplegia with mitochondrial DNA deletions
