Reactive species
Human,Mouse,Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 745-877 of
human NF-κ B2 (Q00653).
Dilution rate
WB 1:500-2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
p52; p100; H2TF1; LYT10; CVID10; LYT-10; NF-kB2; p49/p100; NF-κ B2
Background
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B
(NFkB). The NFkB complex is expressed in numerous cell types and functions as a central
activator of genes involved in inflammation and immune function. The protein encoded by
this gene can function as both a transcriptional activator or repressor depending on its
dimerization partner. The p100 full-length protein is co-translationally processed into a p52
active form. Chromosomal rearrangements and translocations of this locus have been
observed in B cell lymphomas, some of which may result in the formation of fusion proteins.
There is a pseudogene for this gene on chromosome 18. Alternative splicing results in
multiple transcript variants.
