Reactive species
Human,Mouse,Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 265-407 of
human DAZAP1 (Q96EP5).
Dilution rate
WB 1:500-2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Background
In mammals, the Y chromosome directs the development of the testes and plays an
important role in spermatogenesis. A high percentage of infertile men have deletions that
map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps
to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely
oligospermic men. It is thought that the DAZ gene cluster arose from the transposition,
amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell
development and gametogenesis. This gene encodes a RNA-binding protein with two RNP
motifs that was originally identified by its interaction with the infertility factors DAZ and
DAZL. Two isoforms are encoded by transcript variants of this gene
