Reactive species
Human,Mouse,Rat
Immunogen
A synthetic phosphorylated peptide around S79 of human ACC1 (NP_942133.1).
Dilution rate
WB 1:500-2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
ACC; ACAC; ACC1; ACCA; Acac1; hACC1; ACACAD; ACCalpha; ACACalpha; Phospho-ACC1-S79
Background
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotincontaining enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the ratelimiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by
two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under
long term control at the transcriptional and translational levels and under short term
regulation by the phosphorylation/dephosphorylation of targeted serine residues and by
allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript
variants divergent in the 5' sequence and encoding distinct isoforms have been found for
this gene.
