Reactive species
Human,Mouse,Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 448-587 of
human ASB2 (NP_057234.2)
Dilution rate
WB 1:500-2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Background
This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein
family. These proteins play a role in protein degradation by coupling suppressor of cytokine
signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of
a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding
proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation
of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple
isoforms have been observed for this gene
