Reactive species
Human,Mouse,Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 411-510 of human FAP
(NP_004451.2)
Dilution rate
WB 1:500-2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
FAP; DPPIV; FAPA; FAPalpha; SIMP; prolyl endopeptidase FAP; Fibroblast activation protein-α
(FAP)
Background
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging
to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of
epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft
tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or
epithelial-mesenchymal interactions during development, tissue repair, and epithelial
carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have
been found for this gene
