Reactive species
Human,Mouse,Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of
human ASGR1 (NP_001662.1).
Dilution rate
WB 1:500-2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
HL-1; ASGPR; ASGPR1; CLEC4H1; ASGR1
Background
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a
transmembrane protein that plays a critical role in serum glycoprotein homeostasis by
mediating the endocytosis and lysosomal degradation of glycoproteins with exposed
terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may
facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for
liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein
composed of major and minor subunits, which are encoded by different genes. The protein
encoded by this gene is the more abundant major subunit. Alternatively spliced transcript
variants encoding multiple isoforms have been observed for this gene
