Reactive species
Human,Mouse,Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 480-540 of
human UBQLN1 (NP_038466.2).
Dilution rate
WB 1:500-2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
DA41; DSK2; UBQN; XDRP1; PLIC-1; UBQLN1
Background
This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity
with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like
domain and a C-terminal ubiquitin-associated domain. They physically associate with both
proteasomes and ubiquitin ligases, and thus are thought to functionally link the
ubiquitination machinery to the proteasome to affect in vivo protein degradation. This
ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is
found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants
encoding different isoforms have been found for this gene.
