Reactive species
Human,Mouse,Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human GRIK2
(Q13002).
Dilution rate
WB 1:500-2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
EAA4; GLR6; MRT6; GLUK6; GLUR6; GluK2; NEDLAS; GRIK2
Background
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the
mammalian brain and are activated in a variety of normal neurophysiologic processes. This
gene product belongs to the kainate family of glutamate receptors, which are composed of
four subunits and function as ligand-activated ion channels. The subunit encoded by this
gene is subject to RNA editing at multiple sites within the first and second transmembrane
domains, which is thought to alter the structure and function of the receptor complex.
Alternatively spliced transcript variants encoding different isoforms have also been
described for this gene. Mutations in this gene have been associated with autosomal
recessive cognitive disability
