Reactive species
Human,Mouse,Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human
JARID2 (Q92833).
Dilution rate
WB 1:500-2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
JMJ; DIDDF; JARID2
Background
This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing
protein. The encoded protein is a DNA-binding protein that functions as a transcriptional
repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays
an essential role in regulating gene expression during embryonic development. This protein
facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in
multiple transcript variants. Mutations in this gene are associated with chronic myeloid
malignancies.
