Background
This gene is a member of the natriuretic peptide family and encodes a secreted protein
which functions as a cardiac hormone. The protein undergoes two cleavage events, one
within the cell and a second after secretion into the blood. The protein's biological actions
include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion,
and a key role in cardiovascular homeostasis. A high concentration of this protein in the
bloodstream is indicative of heart failure. The presence of myocardial injury is a significant
predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and
there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor
COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and
antifungal activity. Mutations in this gene have been associated with postmenopausal
osteoporosis
