Reactive species
Human,Mouse,Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 202-292 of
human Cyclin D3 (P30281).
Dilution rate
WB 1:500-1:2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
CCND3; cyclin D3; Cyclin D3
Background
The protein encoded by this gene belongs to the highly conserved cyclin family, whose
members are characterized by a dramatic periodicity in protein abundance through the cell
cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct
expression and degradation patterns which contribute to the temporal coordination of each
mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of
CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been
shown to interact with and be involved in the phosphorylation of tumor suppressor protein
Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle
progression through G2 phase into mitosis after UV radiation. Several transcript variants
encoding different isoforms have been found for this gene.
