Reactive species
Human,Mouse,Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 200-295 of human
Cyclin D1 (NP_444284.1).
Dilution rate
WB 1:500-1:1000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
BCL1; PRAD1; U21B31; D11S287E; Cyclin D1
Background
The protein encoded by this gene belongs to the highly conserved cyclin family, whose
members are characterized by a dramatic periodicity in protein abundance throughout the
cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct
expression and degradation patterns which contribute to the temporal coordination of each
mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of
CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been
shown to interact with tumor suppressor protein Rb and the expression of this gene is
regulated positively by Rb. Mutations, amplification and overexpression of this gene, which
alters cell cycle progression, are observed frequently in a variety of human cancers.
