Reactive species
Human,Mouse,Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 241-455 of
human Rig-I/DDX58 (NP_055129.2).
Dilution rate
WB 1:2000- 1:4000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
RIG1; DDX58; RIG-I; RLR-1; SGMRT2; Rig-I/DDX58
Background
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are
putative RNA helicases which are implicated in a number of cellular processes involving RNA
binding and alteration of RNA secondary structure. This gene encodes a protein containing
RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is
involved in viral double-stranded (ds) RNA recognition and the regulation of the antiviral
innate immune response. Mutations in this gene are associated with Singleton-Merten
syndrome 2
