Reactive species
Human,Mouse,Rat
Immunogen
A synthetic phosphorylated peptide around S420 of mouse CGAS (NP_775562.2).
Dilution rate
WB 1:500 - 1:1000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
Mb21d1; E330016A19Rik; Phospho-CGAS-S420
Background
The protein encoded by this gene is a DNA binding cytosolic protein that catalyzes the
synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) after
sensing the presence of DNA in the cytoplasm. cGAMP binds another protein, Stimulator of
interferon genes (STING), leading to the induction of interferons, and a host immune
response. Reduced expression of this gene inhibits interferon induction in the presence of
some viral infections. Alternative splicing results in multiple transcript variants
