Reactive species
Human,Mouse,Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human
TBK1/NAK (Q9UHD2).
Dilution rate
WB 1:1000- 1:4000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
NAK; T2K; IIAE8; FTDALS4; TBK1/NAK
Background
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which
inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the
IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway,
thereby allowing activation and nuclear translocation of the NFKB complex. The protein
encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response
to certain growth factors. The protein is also an important kinase for antiviral innate
immunity response.
