Reactive species
Human,Mouse,Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 11-221 of
PKM1/2(NP_001193728.1).
Dilution rate
WB 1:500 - 1:1000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
PK3; TCB; p58; OIP3; PKM2; CTHBP; THBP1; HEL-S-30; PKM1/2
Background
This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase
that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP,
generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone
and may mediate cellular metabolic effects induced by thyroid hormones. This protein has
been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal
adherence to and invasion of human cells, suggesting a role of this protein in bacterial
pathogenesis. Several alternatively spliced transcript variants encoding a few distinct
isoforms have been reported.
