Reactive species
Human,Mouse,Rat
Immunogen
A synthetic phosphorylated peptide around S724 of human IRE1(NP_001424.3).
Dilution rate
WB 1:1000- 1:5000
Purification process
Affinity purification
Stockpile
-15°C to -25°C/1 year(Do not lower than -25°C)
Other name
IRE1; IRE1P; IRE1a; hIRE1p; Phospho-IRE1-S724
Background
This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The
encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase
domain and an endoribonuclease domain. This protein functions as a sensor of unfolded
proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway
termed the unfolded protein response (UPR). The UPR is an ER stress response that is
conserved from yeast to mammals and activates genes involved in degrading misfolded
proteins, regulating protein synthesis and activating molecular chaperones. This protein
specifically mediates the splicing and activation of the stress response transcription factor Xbox binding protein 1.
