Reactive species
Human,Mouse,Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 470-574 of human
EAAT2(NP_004162.2).
Dilution rate
WB 1:9000 - 1:36000
Purification process
Affinity purification
Stockpile
-15°C to -25°C/1 year(Do not lower than -25°C)
Other name
GLT1; HBGT; DEE41; EAAT2; GLT-1; EIEE41; EAAT2/SLC1A2
Background
This gene encodes a member of a family of solute transporter proteins. The membranebound protein is the principal transporter that clears the excitatory neurotransmitter
glutamate from the extracellular space at synapses in the central nervous system.
Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal
damage from excessive activation of glutamate receptors. Improper regulation of this gene
is thought to be associated with several neurological disorders. Alternatively spliced
transcript variants of this gene have been identified.
