Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Background
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as
an integration point for multiple biochemical signals, and are involved in a wide variety of
cellular processes such as proliferation, differentiation, transcription regulation and
development. This kinase is specifically activated by mitogen-activated protein kinase kinase
5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor
molecules including receptor type kinases, and G protein-coupled receptors. In response to
extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene
expression by phosphorylating, and activating different transcription factors. Four
alternatively spliced transcript variants of this gene encoding two distinct isoforms have
been reported.
