Reactive species
Human,Mouse,Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of
human PD-L1/CD274 (Q9NZQ7)
Dilution rate
WB 1:1000- 1:2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
B7-H; B7H1; PDL1; PD-L1; hPD-L1; PDCD1L1; PDCD1LG1; PD-L1/CD274
Background
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic
and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The
encoded protein is a type I transmembrane protein that has immunoglobulin V-like and Clike domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine
production. During infection or inflammation of normal tissue, this interaction is important
for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor
microenvironments, this interaction provides an immune escape for tumor cells through
cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be
prognostic in many types of human malignancies, including colon cancer and renal cell
carcinoma. Alternative splicing results in multiple transcript variants.
