Reactive species
Human,Mouse,Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 691-770 of human β-
Amyloid(NP_000475.1)
Dilution rate
WB 1:500 - 1:2000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Other name
AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; preA4; CTFgamma; alpha-sAPP; β-
Amyloid(1-42)
Background
This gene encodes a cell surface receptor and transmembrane precursor protein that is
cleaved by secretases to form a number of peptides. Some of these peptides are secreted
and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional
activation, while others form the protein basis of the amyloid plaques found in the brains of
patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides,
having been shown to have bacteriocidal and antifungal activities. Mutations in this gene
have been implicated in autosomal dominant Alzheimer disease and cerebroarterial
amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several
different isoforms have been found for this gene.
