Reactive species
Human;Mouse;Rat
Immunogen
A synthetic phosphorylated peptide around S428 of human ATR (NP_001175.2).
Dilution rate
WB 1:1000 - 1:5000
Purification process
Affinity purification
Stockpile
Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Other name
FRP1; MEC1; SCKL; FCTCS; SCKL1; Phospho-ATR-S428
Background
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor,
activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can
phosphorylate and activate several proteins involved in the inhibition of DNA replication and
mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also
important for fragile site stability and centrosome duplication. Defects in this gene are a
cause of Seckel syndrome 1.
