Reactive species
Human,Mouse,Rat
Gene Name
DHCR24 KIAA0018
Protein name
Delta(24)-sterol reductase (24-dehydrocholesterol reductase) (3-beta-hydroxysterol delta-24-reductase) (Diminuto/dwarf1 homolog) (Seladin-1)
Immunogen
Synthesized peptide derived from human DHCR24
Specificity
This antibody detects endogenous levels of DHCR24 at Human, Mouse,Rat
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Stockpile
-15°C to -25°C/1 year(Do not lower than -25°C)
Function
Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis . In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress . Also protects against amyloid-beta peptide-induced apoptosis .
