Reactive species
Human,Mouse
Gene Name
MCRS1 INO80Q MSP58
Protein name
Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle-regulated factor p78) (INO80 complex subunit J)
Immunogen
Synthesized peptide derived from human MCRS1
Specificity
This antibody detects endogenous levels of MCRS1 at Human, Mouse
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Stockpile
-15°C to -25°C/1 year(Do not lower than -25°C)
Function
Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus . As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues . Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity . Binds to G-quadruplex structures in mRNA . Binds to RNA homomer poly(G) and poly(U) .
