Reactive species
Human,Mouse
Gene Name
DTX2 KIAA1528 RNF58
Protein name
Probable E3 ubiquitin-protein ligase DTX2 (Protein deltex-2) (Deltex2) (hDTX2) (RING finger protein 58)
Immunogen
Synthesized peptide derived from human DTX2
Specificity
This antibody detects endogenous levels of DTX2 at Human, Mouse
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Stockpile
-15°C to -25°C/1 year(Do not lower than -25°C)
Function
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
