Reactive species
Human,Mouse,Rat
Dalton（DA）
Calculated MW: 50 kDa; Observed MW: 45 kDa
Immunogen
Recombinant protein of human KAT1/HAT1
Specificity
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Dilution rate
WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20
Stockpile
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Background
Required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity).
