Reactive species
Human;Rat;Mouse
Antibody type
Polyclonal Antibody
Protein name
Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor)
Immunogen
Synthetic Peptide of Ghrelin Receptor AA range: 290-370
Specificity
Ghrelin Receptor protein(A232) detects endogenous levels of Ghrelin Receptor
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:1000-2000, IHC 1:100-200. IF 1:50-200
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
Other name
Growth hormone secretagogue receptor type 1 (GHS-R;GH-releasing peptide receptor;GHRP;Ghrelin receptor)
Background
This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.[provided by RefSeq, Apr 2010],
Function
disease:Defects in GHSR may be a cause of short stature [MIM:604271]. Short stature is defined by a subnormal rate of growth.,function:Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Pituitary and hypothalamus.,
