Reactive species
Human;Mouse;Rat
Antibody type
Polyclonal Antibody
Protein name
Gasdermin-E,DFNA5,Dfna5h,EG14210,2310037D07Rik .4932441K13Rik ,ICERE 1,ICERE-1,Deafness, autosomal dominant 5,Non-syndromic hearing impairment protein 5,GSDME-CT
Immunogen
Synthesized peptide derived from human GSDME. AA range:400-496
Specificity
The antibody detects endogenous full lenth and c-ternal fragment of gsdme protein,
Constitute
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
IF: 1:50-200 WB: 1:5000-20000 IHC: 1:200-300
Purification process
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
Cleavage at Asp-270 by CASP3 (mature and uncleaved precursor forms) or granzyme B (GZMB) relieves autoinhibition and is sufficient to initiate pyroptosis.
