Reactive species
Human;Rat;Mouse;
Antibody type
Polyclonal Antibody
Gene Name
PCSK9 NARC1 PSEC0052
Immunogen
Synthesized peptide derived from human PCSK9
Specificity
This antibody detects endogenous levels of Human PCSK9
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Other name
Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-;Neural apoptosis-regulated convertase 1;NARC-1;Proprotein convertase 9;PC9;Subtilisin/kexin-like protease PC9)
Background
cofactor:Calcium.,disease:Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant.,enzyme regulation:Inhibited by EGTA.,function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis.,PTM:The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme.,similarity:Belongs to the peptidase S8 family.,similarity:Contains 1 peptidase S8 domain.,subunit:The precursor protein but not the mature protein may form multimers.,tissue specificity:Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.,
Function
urogenital system development, kidney development, liver development, regulation of receptor recycling, negative regulation of receptor recycling, regulation of receptor internalization, positive regulation of receptor internalization,proteolysis, neutral lipid metabolic process, acylglycerol metabolic process, triglyceride metabolic process, phospholipid metabolic process, glycerol ether metabolic process, induction of apoptosis, vacuolar transport, lysosomal transport,steroid metabolic process, cholesterol metabolic process, macromolecule catabolic process, cellular response to starvation, response to endogenous stimulus, response to hormone stimulus, regulation of catabolic process,response to extracellular stimulus, response to organic substance, regulation of receptor activity, positive regulation of macromolecule metabolic process, negative regulation of macromolecule metabolic pro
