Reactive species
Human;Rat;Mouse;
Antibody type
Polyclonal Antibody
Immunogen
Synthesized peptide derived from human IL23A
Specificity
This antibody detects endogenous levels of Human IL23A
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:1000-2000 ELISA 1:5000-20000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Other name
Interleukin-23 subunit alpha (IL-23 subunit alpha;IL-23-A;Interleukin-23 subunit p19;IL-23p19)
Background
developmental stage:Expressed by newborns dendritic cells.,function:Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.,induction:Up-regulated by a wide array of pathogens and pathogen-products together with self-signals for danger or injury. Up-regulated in psoriatic dermal tissues, in dendritic cells of multiple sclerosis patients and in tumors.,similarity:Belongs to the IL-6 superfamily.,subcellular location:Secreted upon association with IL12B.,subunit:Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23.,tissue specificity:Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).,
Function
cell activation, defense response, inflammatory response, immune response, cell proliferation, response to wounding,response to virus, mononuclear cell proliferation, T cell proliferation, T cell activation, innate immune response,leukocyte activation, lymphocyte activation, lymphocyte proliferation, tissue remodeling, leukocyte proliferation,
