Reactive species
Human; Mouse
Antibody type
Polyclonal Antibody
Gene Name
PHF16 JADE3 KIAA0215
Immunogen
Synthesized peptide derived from human JADE3 AA range: 484-534
Specificity
This antibody detects endogenous levels of JADE3 at Human/Mouse
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of a family of large proteins containing PHD (plant homeo domain)-type zinc fingers. The encoded protein may be associated in a nuclear complex that functions in histone H4 acetylation. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2013],
Function
function:Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo.,induction:By estradiol in estrogen-responsive breast cancer cells.,similarity:Belongs to the JADE family.,similarity:Contains 1 PHD-type zinc finger.,subunit:Component of the HBO1 complex composed at least of ING4 or ING5, MYTS2/HBO1, EAF6, and one of PHF15, PHF16 and PHF17.,tissue specificity:Ubiquitously expressed, with highest levels in placenta and uterus.,
