Reactive species
Human; Mouse;Rat
Applications
WB;ELISA;IHC
Antibody type
Polyclonal Antibody
Gene Name
RNF4 SNURF RES4-26
Immunogen
Synthesized peptide derived from human RNF4 AA range: 71-121
Specificity
This antibody detects endogenous levels of RNF4 at Human/Mouse/Rat
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.[provided by RefSeq, Jul 2010],
Function
function:Enhances steroid receptor-mediated transcriptional activation as well as activating basal transcription.,similarity:Contains 1 RING-type zinc finger.,subunit:Interacts with GSCL, Androgen receptor, TCF20, TBP and PATZ1.,tissue specificity:Widely expressed at low levels in many tissues; highly expressed in testis.,
