Reactive species
Human;Rat;Mouse;
Antibody type
Polyclonal Antibody
Immunogen
Synthesized peptide derived from human GLYM AA range: 122-172
Specificity
This antibody detects endogenous levels of GLYM at Human
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1：500-2000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],
Function
catalytic activity:5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine.,cofactor:Pyridoxal phosphate.,function:Interconversion of serine and glycine.,miscellaneous:In eukaryotes there are two forms of the enzymes: a cytosolic one and a mitochondrial one.,pathway:One-carbon metabolism; tetrahydrofolate pathway.,similarity:Belongs to the SHMT family.,subunit:Homotetramer.,
