Reactive species
Human; Mouse
Antibody type
Polyclonal Antibody
Gene Name
FBXO18 FBH1 FBX18
Immunogen
Synthesized peptide derived from human FBX18 AA range: 799-849
Specificity
This antibody detects endogenous levels of FBX18 at Human/Mouse
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1：500-2000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008],
Function
function:DNA-dependent ATPase. Unwinds double-stranded DNA in a 3' to 5' direction.,function:Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.,similarity:Belongs to the helicase family. UvrD subfamily.,similarity:Contains 1 F-box domain.,subunit:Part of a SCF E3 ubiquitin ligase complex consisting of SKP1, CUL1, RBX1 and FBXO18. Interacts with SKP1.,
