Reactive species
Human; Mouse
Antibody type
Polyclonal Antibody
Gene Name
SPPL2A IMP3 PSL2 PSEC0147
Immunogen
Synthesized peptide derived from human SPP2A AA range: 66-116
Specificity
This antibody detects endogenous levels of SPP2A at Human/Mouse
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15. [provided by RefSeq, Feb 2012],
Function
function:Functions as an intramembrane protease. Functions in ITM2B processing.,similarity:Belongs to the peptidase A22B family.,similarity:Contains 1 PA (protease associated) domain.,subunit:Interacts with ITM2B.,
