Reactive species
Human; Mouse
Antibody type
Polyclonal Antibody
Gene Name
PCDH19 KIAA1313
Immunogen
Synthesized peptide derived from human PCD19 AA range: 841-891
Specificity
This antibody detects endogenous levels of PCD19 at Human/Mouse
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a member of the delta-2 protocadherin subclass of the cadherin superfamily. The encoded protein is thought to be a calcium-dependent cell-adhesion protein that is primarily expressed in the brain. Defects in this gene are a cause of epilepsy female-restricted with mental retardation (EFMR). Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010],
Function
developmental stage:Expressed in developing cortical plate, amygdala and subcortical regions and in the ganglionic eminence.,disease:Defects in PCDH19 are the cause of epilepsy, female-restricted, with mental retardation (EFMR) [MIM:300088]; also known as convulsive disorder and mental retardation. EFMR is a condition characterized by seizure onset in infancy or early childhood and cognitive impairment. The disorder is sex-limited, with the phenotype being restricted to females. Males are apparently spared.,function:Potential calcium-dependent cell-adhesion protein.,similarity:Contains 6 cadherin domains.,tissue specificity:Moderately expressed in all regions of the brain examined, with lowest levels found in the cerebellum. Moderate expression is also found in ovary, and low expression in all other tissues tested. Also detected in primary skin fibroblast.,
