Reactive species
Human; Mouse
Antibody type
Polyclonal Antibody
Gene Name
EML4 C2orf2 EMAPL4
Immunogen
Synthesized peptide derived from human EMAL4 AA range: 398-448
Specificity
This antibody detects endogenous levels of EMAL4 at Human/Mouse
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1：500-2000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015],
Function
developmental stage:Strongly overexpressed during mitosis.,function:May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.,similarity:Belongs to the WD repeat EMAP family.,similarity:Contains 9 WD repeats.,
