Reactive species
Human; Mouse
Antibody type
Polyclonal Antibody
Gene Name
ZFYVE1 DFCP1 KIAA1589 TAFF1 ZNFN2A1 PP10436
Immunogen
Synthesized peptide derived from human ZFYV1 AA range: 318-368
Specificity
This antibody detects endogenous levels of ZFYV1 at Human/Mouse
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1：500-2000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],
Function
sequence caution:Translated as Trp.,similarity:Contains 2 FYVE-type zinc fingers.,subcellular location:Resides predominantly in the cisternal stacks of the Golgi.,subunit:Binds to phosphatidylinositol-3-phosphate (PtdIns3P) through its FYVE-type zinc finger.,tissue specificity:Isoform 1 was expressed in all tissues examined, including, brain, placenta, lung, liver, skeletal muscle, pancreas and kidney. Both isoforms, 1 and 2 showed a high expression in heart. Isoform 2 is also detected in the testis.,
