Reactive species
Human; Mouse;Rat
Antibody type
Polyclonal Antibody
Gene Name
CYTH2 ARNO PSCD2 PSCD2L
Immunogen
Synthesized peptide derived from human CYH2 AA range: 156-206
Specificity
This antibody detects endogenous levels of CYH2 at Human/Mouse/Rat
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1：500-2000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],
Function
function:Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF through replacement of GDP with GTP.,similarity:Contains 1 PH domain.,similarity:Contains 1 SEC7 domain.,subunit:Heteromer. Composed of GRASP, CYTH2 and at least one GRM1.,tissue specificity:Ubiquitous.,
