Reactive species
Human; Mouse
Antibody type
Polyclonal Antibody
Immunogen
Synthesized peptide derived from human ZPR1 AA range: 277-327
Specificity
This antibody detects endogenous levels of ZPR1 at Human/Mouse
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1：500-2000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is found in the cytoplasm of quiescent cells but translocates to the nucleolus in proliferating cells. The encoded protein interacts with survival motor neuron protein (SMN1) to enhance pre-mRNA splicing and to induce neuronal differentiation and axonal growth. Defects in this gene or the SMN1 gene can cause spinal muscular atrophy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015],
Function
function:May be a signaling molecule that communicates mitogenic signals from the cytoplasm to the nucleus.,similarity:Belongs to the ZPR1 family.,subcellular location:Translocates to the nucleus after treatment with mitogens.,subunit:Binds to the EGF and PDGF receptors. Binds to the elongation factor 1-alpha (By similarity). Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259.,
