Reactive species
Human; Mouse
Antibody type
Polyclonal Antibody
Gene Name
DENND1B C1orf218 FAM31B
Immunogen
Synthesized peptide derived from human DEN1B AA range: 325-375
Specificity
This antibody detects endogenous levels of DEN1B at Human/Mouse
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1：500-2000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010],
Function
PTM:Isoform 5 is phosphorylated on Tyr-475 and Tyr-484.,similarity:Contains 1 dDENN domain.,similarity:Contains 1 DENN domain.,similarity:Contains 1 uDENN domain.,
