Reactive species
Human;Rat
Antibody type
Polyclonal Antibody
Immunogen
Synthesized peptide derived from human KBTBA AA range: 268-318
Specificity
This antibody detects endogenous levels of KBTBA at Human/Rat
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene is a member of the kelch-like family. The encoded protein contains a BACK domain, a BTB/POZ domain, and 5 Kelch repeats. This protein is thought to function in skeletal muscle development and maintenance. Mutations in this gene have been associated with nemaline myopathy (NM), a rare congenital muscle disorder. [provided by RefSeq, Mar 2015],
Function
function:Required for pseudopod elongation in transformed cells. Substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,pathway:Protein modification; protein ubiquitination.,PTM:Ubiquitinated and probably targeted for proteasome-independent degradation.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 5 Kelch repeats.,subcellular location:Predominantly cytoplasmic but can co-localize with F-actin at the membrane ruffle-like structures at the tips of transformation-specific pseudopodia.,subunit:Interacts with NRAP (By similarity). Part of a complex that contains CUL3, RBX1 and KBTBD10.,tissue specificity:Sarcomeric muscle.,
