Reactive species
Human; Mouse;Rat
Applications
WB;ELISA;IHC
Antibody type
Polyclonal Antibody
Gene Name
SLCO1C1 OATP14 OATP1C1 OATPF SLC21A14
Immunogen
Synthesized peptide derived from human SO1C1 AA range: 634-684
Specificity
This antibody detects endogenous levels of SO1C1 at Human/Mouse/Rat
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009],
Function
function:Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency.,similarity:Belongs to the organo anion transporter (TC 2.A.60) family.,tissue specificity:Highly expressed in brain and in Leydig cells in testis. Detected in many brain regions with the exception of pons and cerebellum.,
