Reactive species
Human; Mouse
Antibody type
Polyclonal Antibody
Gene Name
NUDT10 APS2 DIPP3A
Immunogen
Synthesized peptide derived from human NUD10 AA range: 92-142
Specificity
This antibody detects endogenous levels of NUD10 at Human/Mouse
Constitute
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Polyclonal, Rabbit,IgG
Dilution rate
WB 1：500-2000
Purification process
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene is a member of the nudix (nucleoside diphosphate linked moiety X)-type motif containing family. The encoded protein is a phosphohydrolase and may regulate the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to the regulation of intracellular trafficking. In some populations putative prostate cancer susceptibility alleles have been identified for this gene. Alternatively spliced transcript variants, which differ only in the 5' UTR, have been found for this gene. [provided by RefSeq, Feb 2015],
Function
catalytic activity:Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate.,cofactor:Magnesium or manganese. Manganese may be the true cofactor in vivo.,function:Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyzes the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.,similarity:Belongs to the Nudix hydrolase family. DIPP subfamily.,tissue specificity:Mainly expressed in testis and, at lower level in brain. According to PubMed:12121577, it is widely expressed.,
